(DOWNLOAD) "Exploring Turkish Biodiversity: A Rich Source of Chemical Diversity for Drug Leads Discovery (Report)" by Pure and Applied Chemistry # Book PDF Kindle ePub Free
eBook details
- Title: Exploring Turkish Biodiversity: A Rich Source of Chemical Diversity for Drug Leads Discovery (Report)
- Author : Pure and Applied Chemistry
- Release Date : January 01, 2011
- Genre: Chemistry,Books,Science & Nature,Professional & Technical,Engineering,
- Pages : * pages
- Size : 87 KB
Description
INTRODUCTION Plants produce a diverse range of structurally novel bioactive molecules, making them a rich source of different types of medicines. Traditional medicines are still the mainstay of about 75-80 % of the world population, mainly in the developing world. The history of drug discovery showed that plants are highly rich sources in the search for new active compounds, and they have become a source for the modern pharmaceutical industry. Many synthetic drugs owe their origin to plant-based complementary medicine. Most prescribed drugs in use have been obtained from bioresources. Many new natural productoriginated bioactive compounds effective in treating several diseases have been isolated from different plants, fungi, and microorganisms. Sensitive bioassays for the high-throughput screening (HTS) methods have been developed to screen these plant extracts. The simplest assays are the ones based on the mechanisms of action of a known drug. The assays have also incorporated into efficient testing schemes that are useful to HTS. For example, one assay used for Alzheimer's disease (AD) is based on the inhibition of acetylcholinesterase (AChE). The development of new leads of AChE inhibitors has been realized by the Ellman method using enzyme-linked immunoabsorbent assay (ELISA) microplate-reader for screening of biological sources. The anticholinesterase potential of a number of selected Turkish medicinal plants with various ethnobotanical uses, aiming to discover new candidates for anticholinesterase compounds, are presented in this study.
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